Clinical relevance of soluble c-erbB-2 for patients with metastatic breast cancer predicting the response to second-line hormone or chemotherapy

Concentrations of soluble c-erbB-2 were determined in the sera of 64 patients with distant metastasis from advanced breast cancer receiving second-line hormone or chemotherapy in comparison to 35 breast cancer patients without detectable recurrent disease and 17 healthy blood donors. The sera of non-metastatic breast cancer patients contained s-erbB-2 concentrations similar to those of healthy blood donors. Patients with distant metastasis from advanced breast cancer had significantly higher values of s-erbB-2 in comparison to patients with non-disseminated disease (mean: 59.6 vs. 11.6 U/ml; p = 0.022). A significant correlation was observed between s-erbB-2 serum levels and serum LDH concentrations (p < 0.001), levels of alkaline phosphatase (p < 0.001), and the presence of hepatic metastasis (p = 0.001). Time to tumor progression was significantly shorter in patients with s-erbB-2 levels above 40 U/ml (mean: 23.4 vs. 56.7 months; p = 0.002). Furthermore, breast cancer patients with hepatic metastasis and those with elevated s-erbB-2 serum levels above 40 U/ml had limited response to hormone or chemotherapy. Non-responders had significantly higher s-erbB-2 levels (mean: 270.3, range: 42-500 U/ml;) compared with the responder group (mean: 23.1, range: 0-149 U/ml; p < 0.001). Logistic regression analysis indicated that elevated s-erbB-2 serum levels above 40 U/ml independently predicted an unfavorable response to second-line hormone or chemotherapy in patients with advanced metastatic breast cancer. Copyright (C) 2002 S. KargerAG, Basel

Games International Lawyers Play

Limericks written by alumnus Hans W. Kop

The Effects of Simulation with Cooperative Learning Strategies in a College Sonography Lab

This action research study investigated adding a combination of learning strategies to a sonography lab course and its impact on student performance. The study was conducted in a junior college level sonography lab with 20 female participants between the ages of 20 to 29. The duration of the study was six weeks. Both qualitative and quantitative data tools were utilized. A pre- and post-survey, instructor lab journals, peer review exercises, quizzes, and competencies scores were used to measure effectiveness. The findings indicated an increase in sonography competency scores when compared to the previous year and an increase in the students’ perceived value of the various strategies. The addition of simulation, rehearsal, and peer review exercises yielded positive results. The implications for results, study limitations and further research are discussed

Entropic gravity, minimum temperature, and modified Newtonian dynamics

Verlinde's heuristic argument for the interpretation of the standard Newtonian gravitational force as an entropic force is generalized by the introduction of a minimum temperature (or maximum wave length) for the microscopic degrees of freedom on the holographic screen. With the simplest possible setup, the resulting gravitational acceleration felt by a test mass m from a point mass M at a distance R is found to be of the form of the modified Newtonian dynamics (MOND) as suggested by Milgrom. The corresponding MOND-type acceleration constant is proportional to the minimum temperature, which can be interpreted as the Unruh temperature of an emerging de-Sitter space. This provides a possible explanation of the connection between local MOND-type two-body systems and cosmology.Comment: 12 pages, v6: published versio

Danger of ice formation on airplanes

This paper relates the different types of ice formations that can occur on airplanes and the dangers that they pose

Real-Time Operating System/360

RTOS has a cost savings advantage for real-time applications, such as those with random inputs requiring a flexible data routing facility, display systems simplified by a device independent interface language, and complex applications needing added storage protection and data queuing